The work in the Read de Alaniz Lab has focused around the use of a very versatile and commercially available bio-waste material, furfural. With its origin as an agricultural byproduct of corncobs and oats, furfural has the hidden potential to be utilized as an environmentally friendly and cost efficient material in many industries. Specifically, derivatives of this versatile compound have already been utilized in the discovery and development of the Piancatelli Rearrangement. With the knowledge of how this rearrangement takes place and the conditions necessary, work has begun on developing a controllable ON/OFF trigger system for self-immolative polymers. With the furfural derivatives as a starting material and utilizing not only the Piancatelli Rearrangement, but also the uniqueness that a Diels Alder reaction offers, we have developed some initial studies into controlling the release of cargo from our trigger system.
Advisor: Javier Read de Alaniz